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I uploaded two HowTos to YouTube that illustrate the basic usage of the plugin, which makes use of the algorithms implemented in BigStitcher.
Video 1: Using the Descriptor-based Registration and automate it through macro-recording
Video 2: Calling the Descriptor-based Registration Fiji macro from the command line
Dan White: Need to write docs here for how to use this plugin for measuring chromatic shift in multi channel z stacks, or 2D images of a field of beads, and apply the transform to the biological images.